| Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats |
| R.Sujatha K.C.Chitra C.Latchoumycandane P.P.Mathur |
| 关键词：杀虫剂 林丹 成年老鼠 睾丸 抗氧化系统 类固醇生成酶 |
| 主要内容：Aim: To find out the effect of lindane on testicular antioxidant system and testicular steroidogenesis in adult male rats. Methods: Adult male rats were orally administered with lindane at a dose of 5.0 mg/kg body weight per day for 30 days. Twenty-four hours after the last treatment the rats were killed using anesthetic ether. Testes, epididymis, seminal vesicles and ventral prostate were removed and weighed. A 10% testicular homogenate was prepared and centrifuged at 4℃. The supernatant was used for various biochemical estimations. Results: The body weight and the weights of testes, epididymis, seminal vesicles and ventral prostate were reduced in lindane-treated rats. There was a significant decline in the activities of antioxidant enzymes superoxide dismutase (SOD), catalase and glutathione reductase while an increase in hydrogen peroxide (H2O2) generation was observed. The specific activities of testicular steroidogenic enzymes 3β-hydroxysteroid dehydrogenase and 1713-hydroxysteroid dehydrogenase were decreased. The levels of DNA, RNA and protein were also decreased in lindane-treated rats. Conclusion: Lindane induces oxidative stress and decreases antioxidant enzymes in adult male rats. |
| 《亚洲男性学杂志：英文版》 2001,3(2).-135-138 |
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