| Lead Induced Disorders in Hematopoietic and Drug Metabolizing Enzyme System and Their Protection by Ascorbic Acid Supplementation |
| AnjanaG.VIJ[1] N.K.SATIJA[2] 等 |
| 关键词：铅诱发 造血机能障碍 药物代谢酶系统 铅毒性 维生素C补充 保护作用 |
| 主要内容：Effect of vitamin C supplementation in restoring lead induced alterations in hematopoietic system and drug metabolizing enzymes were investigated in male rats.Intraperitoneal administration of 20mg/kg lead produced a significant inhibition of heme synthesis m blood and liver and drug metabolism in liver.Toxic insult by lead also resulted into a marked decline in tissue thiols and vitamin Clevels.Oral supplementation of vitmin C(100mg/kg for 3 days)completely restored blood delta aminolevulinic acid ehydratase,uroporphyrinogen I synthetase and a few drug metabolizing enzymes.Level of vitamin C and sulfhydryl contents too recovered to a great extent.A marked reduction in blood and liver lead concentration occurred on vitamin C supplementation although renal lead contents were marginally reduced in lead exposed animals.The results,thus,indicate a significant protective action of viatmin C against toxic effects of lead on heme synthesis and drug metabolism. |
| 《生物医学与环境科学：英文版》 1998,11(1).-7-14 |
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