| A COMPARATIVE STUDY ON CELLULAR ELECTROPHYSIOLOGIC CHANGES BETWEEN LASER PHOTOCOAGULATION AND RADIOFREQUENCY ABLATION |
| 方丕华 王方正 张奎俊 刘北英 曲晋生 陈新 孙瑞龙 |
| 关键词：激光凝固术 射频消融术 电生理学 膜蛋白 心律失常 |
| 主要内容：In order to investigate the differences of cellular elecrrophysiologic changes between laser pholocoagulation (LP) and radiofrequency ablation (RFA), transmembrane potentials were recorded at 0. 5,1,3, 5,8mm from lesions before and after LP and RFA had been performed respectively on 15 endocardial tissues removed from 15 adult rabbits in each group. Resting potential(RP), action potential amplitude(APA),maximum rare of upstroke velociry (dV/dT), and action potential duration at 50 percent of repolarization(APD50) decreased at 0. 5, 1,3 mm from lesions in RF, so did all of them at 0. 5,1 tara in LP, bon all transmembrane potential variables were almost normal at 3 mm in LP. Furthermore, almost all the transmembrane potential variables at 0. 5 1,3 mm in RFA went down much lower than those in LP(P<0. 01).There was no difference in all transmembrane potential variables at 5, 8mm between LP and RFA. APD 90 had no difference at raring distance in both the groups. Elecrrophysiologic abnormalities of border zone of injured bur nonnecrotie myocardiurn around the lesions of laser photocoagulation are much less than those of radiofrequency ablation in strength, and much smaller irL scope, which suggest that unfavorable efects of laser photocoagulation on hemodynamics and arrhythraogenicity would be less than those of radiofrequency ablation. |
| 《中国医学科学杂志：英文版》 1998,13(4).-234-237 |
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