| Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice |
| 魏道严[1] 金敖兴[2] 等 |
| 关键词：肿瘤 低剂量辐照 肿瘤分解 变异 |
| 主要内容：By using the models of tumor blood-borne metastasis and spontaneous one,the antitumor metastasis effect of 75mGy X-ray whole body irradiation on tumor bearing mice is investigated.The results demonstrate that irradiation could significantly inhigit B16 Melanoma blood borne pulmonary metastases(P<0.05) and Lewis lung carcinoma(LLC) spontaneous pulmonary metastases(P<0.01),The immunofunction test of B16 melanoma beraing mice shows that the NK(P<0.05) and LAK(P<0.001) cytotoxicities,and responsibility of splenocytes to IL-2(P<0.005) for the irradiated group are increased greatly comperaed with those of control group.These results suggest that the enhancement of immunofunctions is induced by low dose radiation to raise antitumor metastasis effects. |
| 《核技术：英文版》 1996,7(3).-180-182 |
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